PhD candidate ‘Magnetic resonance image guided SIRT’

Status Open
Beschikbaar per -
Werkgever Radboudumc
Afdeling Radiologie, Imaging techniques, Promotietraject, Radiation therapy
Dienstverband Voltijd
Werktijden 36 uur per week
Locatie Nijmegen
Sluitingsdatum 24 juni, 2022
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Overige informatie


Profile

You have a Master’s degree in Clinical technology / Technical medicine / Medicine and affinity with experiments in that area. You are eager to work on this multi-disciplinary translational project, in-depth pre-clinical feasibility and modelling studies in a laboratory and medical imaging environment combined with patient-related clinical research.

Furthermore:

  • Demonstrated interest in solving complex modelling.
  • An interest in high-tech medicine, clinical physics, experience with medical imaging techniques (CT, MRI, SPECT).
  • Permit to work with radioactivity (or willing to obtain this permit).
  • Permit to work with laboratory animals; article-9 (or willing to obtain this permit).
  • Well-developed communicational and social skills directed towards working in a team.
  • Enthusiastic and strong motivation to successfully complete a PhD.

 

Job description

Your PhD project will focus on in and ex-vivo modelling and testing to enable magnetic resonance image guided SIRT. Will you join our ambitious team? 

We will develop within an European Eurostars project, a turn-key platform – DELIVR – for precision radiation dosing in MRI-guided SIRT for liver tumours. The DELIVR platform consists of MRI compatible interventional hardware (catheters and guidewires) together with a real-time tracking and dosimetry software for on-the-fly dose adjustment under MRI. The platform will enable clinicians to administer a precise radiation dose accurately at the tumour location, thus drastically improving SIRT response rates and reducing side effects. This project will accelerate the completion of the needed development and validation steps towards reaching a preclinical proof-of-concept of the platform.

The project is divided in three major subprojects wherein the technical aspects are developed that are necessary for real-time MRI-guided SIRT:

  • Development of a MRI compatible and visible catheter
  • Complementary machine learning algorithms for visualization of the catheter
  • Fast precision dosimetry software to guide treatment

These three technical aspects must be combined and tested in phantoms, ex-vivo livers, animal studies and in case of positive results also in patients. The combined techniques will be the main part of your project within the Radboudumc.

The main tasks for you will be to perform the preclinical proof-of-concept: In line with the technology framework for MRI-guided interventional procedures, you will optimize our workflow for perfused phantom testing using (radioactive) microspheres and catheters. The catheters will be equipped with a MR marker, which can be followed by MRI. These studies will allow assessment of MR safety, heating, visibility and dose estimation capabilities of the DELIVR solution. The phantom results are also necessary to optimize the coating and software parameters. Animal experiments using pig models will be performed to deliver the data needed for entering clinical evaluation phase.

You will be positioned in the MAGIC research group of Prof Dr. Jurgen Fütterer and Dr Frank Nijsen at the department of Medical Imaging, Radboudumc in Nijmegen and you will be part of a dynamic, multidisciplinary team. Within this project you will work together with several colleague PhD candidates and senior researchers. Preclinical work and the validation on patients treated with radioembolization will be performed in the Radboudumc.

Tasks and responsibilities

  • Analysis of scientific data and the set-up of list of parameters that will be investigated.
  • Writing the animal study and get Animal Ethics Committee approval.
  • Phantom development and testing of catheters and software in different MRI scanner environments.
  • The development of an image guided radioembolization procedure in phantoms, ex-vivo and in-vivo animal model.
  • Determine safety and effect on image quality of DELIVR in phantom studies.
  • Determine precision of the tracking software and catheter visualization.
  • Report in collaboration with a multidisciplinary group consisting of interventional radiologist, surgeon and (medical) physicists on a modified Failure Mode and Effect Analysis (FMEA).
  • Report in English writing and communication with the collaborating partners.
  • Write scientific publications and present findings at (inter)national scientific meetings.
  • Work in a team with other scientists and clinicians to plan, discuss, and perform research in a stimulating environment.

Department

The Department of Medical Imaging of the Radboudumc Nijmegen is headed by Prof. Dr. Mathias Prokop. The Radboudumc is an academic center with focus on research, education and patient care. The department has extensive expertise in imaging and uses state-of the art CT, ultrasound, MRI and nuclear imaging. Advanced MRI facilities for both patient care and (animal experiments) research are available and accessible. Within the Department of Radiology oncology is an important focus of research and patient care. Both pre-clinical and clinical research can be performed in the animal lab (PRIME) and in the Medical Innovation & Technology expert Centre (MITeC), which is a conglomerate of three Operating Rooms (OR’s) in the newly built OR-complex in the Radboudumc.

Our project DELIVR
Each year, over 1.5 million people worldwide develop liver tumors. Selective Internal Radiation Therapy (SIRT), also called radioembolization, is a treatment option for patients suffering from liver tumors that do not benefit from conventional therapy. During the treatment, radioactive microspheres are injected into the liver artery that supplies the tumor, where they lodge in and around the tumor and deliver a high local radiation dose. SIRT has emerged as a promising treatment modality in inoperable primary liver malignancies. However, challenges related to imprecise radiation dose estimation and difficulties in delivering the radiation accurately at the tumour location have hampered its full-scale clinical adoption. We aim to meet these challenges with the fully MRI guided SIRT technique at a standard MRI apparatus. Therefore, we will develop within an European Eurostars project, a turn-key platform – DELIVR – for precision radiation dosing in MRI-guided SIRT for liver tumours.

Research Institutes
At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises). Read what it is like to do a PhD at the Radboud University Medical Center.

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc

 

Interested? Apply before 24 june 2022!

 

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