|Afdeling||Urologie, Nucleaire Geneeskunde, Prostate MR Expertise Center (PMRC), Radiologie|
|Werktijden||36 uur per week|
|Sluitingsdatum||31 maart, 2019|
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Patients with prostate cancer do not die from the primary tumor, but from (extended) metastatic disease. One of the first steps towards extended metastatic disease is the presence of lymph node metastases, which is an important factor determining the patients’ prognosis. With continuously improving opportunities to very selectively treat small numbers of metastatic sites it is of utmost importance to accurately diagnose the first signs of oligometastatic disease and to define its extent and aggression.
Within our department nano-MRI as well as 68Ga/18F-PSMA PET-CT are two unique complementary techniques for diagnosis of nodal disease, even in very small lymph nodes. However, the biggest challenge we currently face is the surgical removal of these nodes, to histopathologically validate our imaging findings, and to provide guidance to treat oligometastatic disease with curative intent.
The main focus of this PhD project will be to combine pre- and intra-operative imaging for the detection of lymph node metastases to improve the gold standard for pre-operative imaging techniques and to improve the surgical outcome in prostate cancer patients who are at risk of having lymph node metastases. For this, a prospective clinical study will be started in patients with prostate cancer who are eligible for surgical lymph node dissection. Pre-operative 68Ga/18F-PSMA PET-CT and nano-MRI will be acquired, and during surgery a gamma probe will be used for exact localization and identification of suspicious lymph nodes.
Tumorous and non-tumorous lymph nodes as determined on 7T MRI images and by histopathology (gold standard) will be retrospectively assessed on the pre-operatively acquired images.
The PhD candidate will have a pivotal role in the project and collaborate with researchers and clinicians from the Prostate MR Expertise Center (PMRC), the radiology and nuclear medicine research groups and the urology department.
Tasks and responsibilities
Department of Radiology and Nuclear Medicine
The Department of Radiology and Nuclear Medicinehas long-standing research lines on the development and clinical translation of radiolabeled tracers for imaging as well as top-level diagnostic imaging with advanced MRI methods. Within the department, there is a strong focus on translational research by collaborations between basic scientists and clinical researchers.
The department has excellent research facilities, including level B radionuclide laboratories, a preclinical imaging center (PRIME) and state-of-the art clinical imaging facilities including MRI, CT, ultrasound, PET, SPECT, and optical imaging. There is also a strong link to the MITeC operating rooms for intra-operative imaging studies. Research is divided over several research groups, including senior scientists, PhD students, medical doctors, and research technicians.
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The gross monthly salary, depending on education will be scale 10A (max. € 2.992) or scale 10 (max. € 4.361) based on a full-time working week (excl. vacation bonus and 8.3% end of year payments).
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
Comments and contact information
All additional information about the vacancy can be obtained from Dr. Mark Rijpkema, associate professor, via +31 (24) 361 45 11.
Recruitment agencies are asked not to respond to this job posting.